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PD-L1 Protein (AA 19-238) (His tag)

HPLC verified PD-L1 Origine: Humain Hôte: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active
N° du produit ABIN2181639
  • Antigène Voir toutes PD-L1 Protéines
    PD-L1 (CD274 (PD-L1))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 19-238
    Origine
    • 41
    • 18
    • 6
    • 5
    • 4
    • 3
    • 1
    Humain
    Source
    • 46
    • 9
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette PD-L1 protéine est marqué à la His tag.
    Séquence
    AA 19-238
    Attributs du produit
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26 kDa. The protein migrates as 35-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Pureté
    >98 % as determined by SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Classe de qualité
    HPLC verified
    Top Product
    Discover our top product PD-L1 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Li, Ren, Zhao, Lou: "PD-L1 aptamer isolation via Modular-SELEX and its applications in cancer cell detection and tumor tissue section imaging." dans: The Analyst, Vol. 146, Issue 9, pp. 2910-2918, (2021) (PubMed).

    Lu, Xue, Deng, Zhou, Yu, Deng, Huang, Yi, Liang, Wang, Shen, Tong, Wang, Li, Song, Li, Su, Ding, Gong, Zhu, Wang, Zou, Zhang, Li, Zhou, Liu, Yu, Wang, Zhang, Yin, Xia, Zeng, Zhou, Ying, Chen, Wei, Li et al.: "Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer. ..." dans: Nature medicine, Vol. 26, Issue 5, pp. 732-740, (2020) (PubMed).

    Wang, Ni, Zhou, He, Gao, Wu, Wu, Wu, Qiu, Zhou, Chen, Pan, Huang, Li, Bian, Yang, Miao, Liu: "Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity." dans: Cancer immunology, immunotherapy : CII, (2020) (PubMed).

    Chen, Xu, Du, Hou, Fan, Wu, Yan: "Enhanced Expression of PD-L1 on Microglia After Surgical Brain Injury Exerts Self-Protection from Inflammation and Promotes Neurological Repair." dans: Neurochemical research, Vol. 44, Issue 11, pp. 2470-2481, (2019) (PubMed).

    Fromm, de Silva, Johannes, Patel, Hornblower, Schreiber: "Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy." dans: Journal for immunotherapy of cancer, Vol. 6, Issue 1, pp. 149, (2018) (PubMed).

    Lai, Huang, Wang, Lin, Yang: "A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects." dans: Molecular therapy. Nucleic acids, Vol. 5, Issue 12, pp. e397, (2016) (PubMed).

  • Antigène
    PD-L1 (CD274 (PD-L1))
    Autre désignation
    PD-L1 (PD-L1 Produits)
    Synonymes
    B7-H Protein, B7H1 Protein, PD-L1 Protein, PDCD1L1 Protein, PDCD1LG1 Protein, PDL1 Protein, A530045L16Rik Protein, B7h1 Protein, Pdcd1l1 Protein, Pdcd1lg1 Protein, Pdl1 Protein, RGD1566211 Protein, CD274 molecule Protein, CD274 antigen Protein, programmed cell death 1 ligand 2 Protein, CD274 Protein, Cd274 Protein, PDCD1LG2 Protein
    Sujet
    Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
    Poids moléculaire
    26.0 kDa
    NCBI Accession
    NP_054862
    Pathways
    Cancer Immune Checkpoints
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