DIABLO Protein (AA 56-239) (His tag)
-
- Antigène Voir toutes DIABLO Protéines
- DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 56-239
-
Origine
- Humain
-
Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette DIABLO protéine est marqué à la His tag.
- Séquence
- AA 56-239
- Attributs du produit
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.7 kDa. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product DIABLO Protéine
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- 20 mM HEPES, 150 mM NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
-
- Antigène
- DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
- Autre désignation
- SMAC (DIABLO Produits)
- Synonymes
- smac Protein, smac3 Protein, diablo-s Protein, 0610041G12Rik Protein, 1700006L01Rik Protein, AU040403 Protein, Smac Protein, DFNA64 Protein, SMAC Protein, DBO Protein, XSmac Protein, diablo, IAP-binding mitochondrial protein Protein, diablo IAP-binding mitochondrial protein Protein, diablo, IAP-binding mitochondrial protein L homeolog Protein, diablo Protein, Diablo Protein, DIABLO Protein, diablo.L Protein
- Sujet
- Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
- Poids moléculaire
- 21.7 kDa
- NCBI Accession
- NP_063940
- Pathways
- Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
-