Mesothelin Protein (MSLN) (AA 296-580) (Fc Tag,Biotin)
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- Antigène Voir toutes Mesothelin (MSLN) Protéines
- Mesothelin (MSLN)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 296-580
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Mesothelin protéine est marqué à la Fc Tag,Biotin.
- Marque
- MABSol®,UltraLys
- Séquence
- AA 296-580
- Specificité
- The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
- Attributs du produit
- This protein carries a human IgG1 Fc fragment at the N-terminus. The protein has a calculated MW of 59.6 kDa. The protein migrates as 60-68 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product MSLN Protéine
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- Commentaires
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A chemically labeled biotinylated protein with ultra sensitivity.
The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity. - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
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Engineered Fn3 protein has targeted therapeutic effect on mesothelin-expressing cancer cells and increases tumor cell sensitivity to chemotherapy." dans: Biotechnology and bioengineering, (2019) (PubMed).
: "Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding." dans: PLoS ONE, Vol. 13, Issue 5, pp. e0197029, (2018) (PubMed).
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Engineered Fn3 protein has targeted therapeutic effect on mesothelin-expressing cancer cells and increases tumor cell sensitivity to chemotherapy." dans: Biotechnology and bioengineering, (2019) (PubMed).
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- Antigène
- Mesothelin (MSLN)
- Autre désignation
- Mesothelin (MSLN Produits)
- Synonymes
- MPF Protein, SMRP Protein, MSLN Protein, mesothelin Protein, MSLN Protein, Msln Protein, LOC611363 Protein, LOC100524016 Protein
- Sujet
- Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
- Poids moléculaire
- 59.1 kDa
- Pathways
- EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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