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Mesothelin Protein (MSLN) (AA 296-580) (Fc Tag,Biotin)

MSLN Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN2444166
  • Antigène Voir toutes Mesothelin (MSLN) Protéines
    Mesothelin (MSLN)
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 296-580
    Origine
    • 45
    • 12
    • 4
    • 2
    Humain
    Source
    • 46
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette Mesothelin protéine est marqué à la Fc Tag,Biotin.
    Marque
    MABSol®,UltraLys
    Séquence
    AA 296-580
    Specificité
    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
    Attributs du produit
    This protein carries a human IgG1 Fc fragment at the N-terminus. The protein has a calculated MW of 59.6 kDa. The protein migrates as 60-68 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
    Pureté
    >95 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product MSLN Protéine
  • Commentaires

    A chemically labeled biotinylated protein with ultra sensitivity.
    The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
    Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
  • Sirois, Deny, Li, Fall, Moore: "Engineered Fn3 protein has targeted therapeutic effect on mesothelin-expressing cancer cells and increases tumor cell sensitivity to chemotherapy." dans: Biotechnology and bioengineering, (2019) (PubMed).

    Sirois, Deny, Baierl, George, Moore: "Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding." dans: PLoS ONE, Vol. 13, Issue 5, pp. e0197029, (2018) (PubMed).

  • Antigène
    Mesothelin (MSLN)
    Autre désignation
    Mesothelin (MSLN Produits)
    Synonymes
    MPF Protein, SMRP Protein, MSLN Protein, mesothelin Protein, MSLN Protein, Msln Protein, LOC611363 Protein, LOC100524016 Protein
    Sujet
    Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
    Poids moléculaire
    59.1 kDa
    Pathways
    EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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