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PUMA Protein (AA 76-170) (His tag,Strep II tag)

BBC3 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant ~95 % WB, ELISA, MS
N° du produit ABIN2468998
  • Antigène Voir toutes PUMA (BBC3) Protéines
    PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 76-170
    Origine
    • 7
    • 2
    • 1
    Humain
    Source
    • 4
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette PUMA protéine est marqué à la His tag,Strep II tag.
    Application
    Western Blotting (WB), ELISA, Mass Spectrometry (MS)
    Pureté
    ~95 %
    Top Product
    Discover our top product BBC3 Protéine
  • Indications d'application
    This recombinant protein can be used for WB, ELISA, MS.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    1X PBS containing 0.1 % SDS and 0.02 % NaN
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
    Stock
    -80 °C
    Stockage commentaire
    Store in working aliquots at -70 °C.
  • Antigène
    PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
    Autre désignation
    PUMA (BBC3 Produits)
    Synonymes
    BBC3 Protein, Puma Protein, JFY-1 Protein, JFY1 Protein, PUMA Protein, PUMA/JFY1 Protein, BCL2 binding component 3 Protein, Bcl-2 binding component 3 Protein, BBC3 Protein, Bbc3 Protein, bbc3 Protein
    Sujet
    Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-? and PUMA-? (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. This PUMA recombinant protein is recognized by several ProSci PUMA monoclonal antibodies, but not the two polyclonal antibodies (PSI # 3041 and 3043).
    Poids moléculaire
    15 kDa (Calculated)
    ID gène
    27113
    OMIM
    56748610
    UniProt
    Q9BXH1
    Pathways
    Signalisation p53, Positive Regulation of Endopeptidase Activity
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