c-FOS Protein (full length) (His tag)

N° du produit ABIN2669410

Détail du produit

Antigène: c-FOS (c-Fos) (c-Fos)

Type de proteíne: Recombinant

Attributs du protein: full length

Origine: Humain

Source: Baculovirus

Purification/Conjugué: Cette c-FOS protéine est marqué à la His tag.

Application: Protein Interaction (PI)

Attributs du produit: Recombinant c-Fos was expressed from full length (accession number NM 003131) with an amino terminal polyhistidine tag in a baculovirus system and purified by an affinity column in combination with FPLC chromatography. The purified recombinant protein is greater than 90 % homogeneous and contains no detectable protease, DNase and RNase activity.

Purification: Purified by an affinity column in combination with FPLC chromatography.

Pureté: The purified recombinant protein is greater than 90 % homogeneous and contains no detectable protease, DNase and RNase activity.

Information d'application

Indications d'application: Recombinant c-Fos is suitable for DNA and protein-protein interaction assays. 100 ng is sufficient for DNA-protein and protein-protein interaction studies. The molecular weight of the protein is ~50 kDa. The standard curve for TransAM® AP-1 c-Fos was generated using the range of 40-2.5 ng of protein. NOTE: The presence of Poly [d(I-C)] in buffers may affect protein functionality and should be avoided.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/μL

Détail du antigène

Antigène: c-FOS (c-Fos) (c-Fos)

Autre désignation: C-Fos (c-Fos Produits)

Synonymes: AP-1 Protein, C-FOS Protein, p55 Protein, c-fos Protein, D12Rfj1 Protein, cFos Protein, cFOS Protein, fos Protein, Fos proto-oncogene, AP-1 transcription factor subunit Protein, FBJ osteosarcoma oncogene Protein, proto-oncogene c-Fos-like Protein, FOS Protein, Fos Protein, LOC101078177 Protein

Sujet: C-Fos is one of the proteins that form the heteromeric AP-1 transcription factor complex. AP-1 proteins play a role in the expression of many genes involved in the regulation of cellular processes such as differentiation, proliferation and apoptosis. The transcription factor AP-1 is composed of a mixture of heterodimeric protein complexes derived from the Fos and Jun families, including c-Fos, FosB, Fra-1, c-Jun, JunB and JunD. c-Fos is a nuclear phosphoprotein that forms a tight but non-covalently linked complex with the Jun/AP-1 transcription factor. In the heterodimer, Fos and Jun/AP-1 basic regions each seem to interact with symmetrical DNA half sites. Upon TGF-β activation, c-Fos forms a multimeric SMAD3/SMAD4/Jun/Fos complex at the AP-1/SMAD-binding site to regulate TGF-β-mediated signaling. c-Fos has a critical function in regulating bone morphogenesis.

Pathways: S100 Proteins