PRMT2 Protein (DYKDDDDK Tag)
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- Antigène Voir toutes PRMT2 Protéines
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Baculovirus
- Purification/Conjugué
- Cette PRMT2 protéine est marqué à la DYKDDDDK Tag.
- Application
- Enzyme Activity Assay (EAA), Screening Assay (ScA)
- Attributs du produit
- Recombinant PRMT2 (accession number NP_996845.1) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 47.6 kDa.
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- Discover our top product PRMT2 Protéine
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- Indications d'application
- Recombinant PRMT2 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. Specific Activity: PRMT2 methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4.May methylate H3R8 and H4.
- Restrictions
- For Research Use only
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- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- Stock
- -80 °C
- Stockage commentaire
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- Antigène
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Autre désignation
- PRMT2 (PRMT2 Produits)
- Synonymes
- PRMT2 Protein, DKFZp459N1919 Protein, HRMT1L1 Protein, Hrmt1l1 Protein, AI504737 Protein, protein arginine methyltransferase 2 Protein, protein arginine methyltransferase 2 L homeolog Protein, protein arginine N-methyltransferase 2 Protein, PRMT2 Protein, Prmt2 Protein, prmt2.L Protein
- Sujet
- PRMT2 (Protein Arginine Methyltransferase 2) is a member of the protein arginine N-methyltransferase (PRMT) family that is capable of monomethylating and asymmetrically dimethylating arginine residues. PRMT2 methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4. PRMT2, along with NCOA2, acts as a coactivator of androgen receptor (AR)-mediated transactivation. PRMT2 also acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. PRMT2 enhances PGR, PPARY, RARA-mediated transactivation and may inhibit NFκB transcription and promote apoptosis. PRMT2 is known to repress E2F1 transcriptional activity in an Rb-dependent manner and may be involved in growth regulation.
- Poids moléculaire
- 47.6 kDa
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding
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