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PRMT1 Protein (DYKDDDDK Tag)

PRMT1 Origine: Humain Hôte: Baculovirus Recombinant EAA, ScA
N° du produit ABIN2669672
  • Antigène Voir toutes PRMT1 Protéines
    PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))
    Type de proteíne
    Recombinant
    Origine
    • 9
    • 3
    • 2
    • 1
    Humain
    Source
    • 5
    • 3
    • 2
    • 2
    • 1
    Baculovirus
    Purification/Conjugué
    Cette PRMT1 protéine est marqué à la DYKDDDDK Tag.
    Application
    Enzyme Activity Assay (EAA), Screening Assay (ScA)
    Attributs du produit
    Recombinant PRMT1 (accession number NP_938074.2) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 42 kDa.
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    Discover our top product PRMT1 Protéine
  • Indications d'application
    Recombinant PRMT1 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. Specific Activity: H3R8 and H4R3 methylase. HMT Assay Conditions: 50 mM TrisCl, pH 8.6, 0.02 % Triton X-100, 2 mM MgCl2, 1 mM TCEP, 100 μM SAM, 30 ng/μl Recombinant Octamers, 30 ng/μl Recombinant PRMT1 protein at 2 hours at room temperature. Activity was detected by fluorography.
    Restrictions
    For Research Use only
  • Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
    Stock
    -80 °C
    Stockage commentaire
    Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
  • Antigène
    PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))
    Autre désignation
    PRMT1 (PRMT1 Produits)
    Synonymes
    ANM1 Protein, HCP1 Protein, HRMT1L2 Protein, IR1B4 Protein, 6720434D09Rik Protein, AW214366 Protein, Hrmt1l2 Protein, Mrmt1 Protein, 3E10 Protein, anm1 Protein, hcp1 Protein, hrmt1l2 Protein, ir1b4 Protein, prmt1 Protein, prmt1b Protein, xPRMT1b Protein, xprmt1 Protein, xPRMT1 Protein, ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 1A Protein, ATPRMT1A Protein, F6F22.30 Protein, F6F22_30 Protein, protein arginine methyltransferase 1A Protein, DDBDRAFT_0183976 Protein, DDBDRAFT_0235399 Protein, DDB_0183976 Protein, DDB_0235399 Protein, PRMT1 Protein, DKFZp459J1326 Protein, fb39h07 Protein, wu:fb39h07 Protein, zf1 Protein, zgc:66201 Protein, protein arginine methyltransferase 1 Protein, protein arginine N-methyltransferase 1 Protein, protein arginine methyltransferase 1 L homeolog Protein, protein arginine methyltransferase 1 S homeolog Protein, protein arginine methyltransferase 1A Protein, protein arginine N-methyltransferase-1 Protein, protein arginine N-methyltransferase Protein, protein arginine methyltransferase Protein, PRMT1 Protein, Prmt1 Protein, prmt1.L Protein, prmt1.S Protein, PRMT1A Protein, prm-1 Protein, EDI_007800 Protein, Smp_029240.3 Protein, prmt1 Protein
    Sujet
    PRMT1 (protein arginine N-methyltransferase 1) is a member of the protein arginine N-methyltransferase (PRMT) family capable of monomethylating and asymmetrically dimethylating arginine residue in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. PRMT1 specifically methylates arginine 3 on histone H4 (H4R3), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, PRMT1 represses STAT1 transcriptional activity in the late phase of interferon gamma (IFN-gamma) signaling. PRMT1 may be involved in the regulation of TAF15 transcriptional activity and may act as an activator of estrogen receptor (ER)-mediated transactivation. It may also play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation by modulating p38 MAPK pathways.
    Poids moléculaire
    42 kDa
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