MLL/KMT2A Protein (AA 3735-3973) (GST tag)

N° du produit ABIN6579161

Détail du produit

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Type de proteíne: Recombinant

Attributs du protein: AA 3735-3973

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MLL/KMT2A protéine est marqué à la GST tag.

Application: Enzyme Activity Assay (EAA), Screening Assay (ScA)

Attributs du produit: The peptide corresponding to amino acids 3735 - 3973 of the MLL / HRX protein (accession number NP_001184033.1) was expressed in E. coli. The peptide contains the SET domain of MLL that is responsible for methyltransferase activity. Recombinant MLL / HRX - SET contains an N-terminal GST tag with a molecular weight of 53.7 kDa.

Information d'application

Indications d'application: Recombinant MLL / HRX - SET is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.

Restrictions: For Research Use only

Stockage

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.

Détail du antigène

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Autre désignation: MLL / HRX (MLL Produits)

Synonymes: ALL-1 Protein, CXXC7 Protein, HRX Protein, HTRX1 Protein, MLL Protein, MLL/GAS7 Protein, MLL1A Protein, TET1-MLL Protein, TRX1 Protein, WDSTS Protein, 6430520K01 Protein, All1 Protein, Cxxc7 Protein, Mll Protein, Mll1 Protein, mKIAA4050 Protein, lysine methyltransferase 2A Protein, lysine (K)-specific methyltransferase 2A Protein, KMT2A Protein, Kmt2a Protein

Sujet: Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), or MLL, also known as HRX, is a Trithorax-group protein that function collectively to promote gene expression. MLL is a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The protein contains multiple conserved functional domains. In particular, the SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. The SET domain is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Poids moléculaire: 53.7 kDa

Pathways: L'effet Warburg