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p53 Protein (His tag)

TP53 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant STD, PI, in vitro Active
N° du produit ABIN2669713
  • Antigène Voir toutes p53 (TP53) Protéines
    p53 (TP53) (Tumor Protein P53 (TP53))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 17
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    Humain
    Source
    • 25
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    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette p53 protéine est marqué à la His tag.
    Application
    Standard (STD), Protein Interaction (PI), In vitro Assay (in vitro)
    Attributs du produit
    p53 is a tumor suppressor protein functioning as a sequence-specific transcription factor important for cell cycle arrest, apoptosis, and DNA-damage response. Recombinant p53, transcript variant 1, was expressed in E. coli from human cDNA (accession number NM_000546.5) with an N-terminal polyhistidine tag. Active Motif also offers Recombinant p53 protein (Catalog No. 31103) that was expressed in Baculovirus.
    Top Product
    Discover our top product TP53 Protéine
  • Indications d'application
    Recombinant p53 is suitable for use in Active Motif's TransAM® assay as a protein standard, in vitro transcription assays, protein-protein interactions and protein-DNA interaction studies. A recommended starting point for in vitro transcription assays is 20-100 ng per reaction. The molecular weight of the protein is 53 kDa.
    Restrictions
    For Research Use only
  • Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
    Stock
    -80 °C
    Stockage commentaire
    Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
  • Antigène
    p53 (TP53) (Tumor Protein P53 (TP53))
    Autre désignation
    p53 (TP53 Produits)
    Synonymes
    BCC7 Protein, LFS1 Protein, P53 Protein, TRP53 Protein, p53 Protein, Trp53 Protein, brp53 Protein, drp53 Protein, etID22686.5 Protein, fb40d06 Protein, wu:fb40d06 Protein, zgc:111919 Protein, Tp53 Protein, bbl Protein, bfy Protein, bhy Protein, p44 Protein, tp53 Protein, Xp53 Protein, TP53 Protein, tumor protein p53 Protein, cellular tumor antigen p53 Protein, transformation related protein 53 Protein, tumor protein p53 L homeolog Protein, TP53 Protein, CpipJ_CPIJ002758 Protein, Tp53 Protein, tp53 Protein, Trp53 Protein, tp53.L Protein
    Sujet
    P53 is the most important tumor suppressor in the genome. It is responsive to numerous genotoxic stresses, which activates its transcription factor activity, in turn causing cell-cycle arrest by activating expression of p21 Cip/WAF. Mutant p53 that has lost its DNA-binding function interferes with the activity of native p53 and leads to oncogenic transformation. Alternatively, transformation may be caused by overexpression of Mdm2/Hdm2, an ubiquitin ligase specific for p53, which causes its destabilization. Inactivation of p53 is often coincident with hyperactivation of NFκB (NFκB p50 and NFκB p65), both of which serve to inhibit apoptosis.
    Pathways
    Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg
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