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CLCF1 Protein (Transcript Variant 1)

CLCF1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
N° du produit ABIN2712862
  • Antigène Voir toutes CLCF1 Protéines
    CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    Transcript Variant 1
    Origine
    • 6
    • 4
    • 3
    Humain
    Source
    • 9
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    Functional Studies (Func), Antibody Production (AbP), Standard (STD), Protein Interaction (PI)
    Specificité
    Optimal preservation of protein structure, post-translational modifications and functions.
    Attributs du produit
    • Recombinant human CLCF1 (transcript variant 1) protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.
    Pureté
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    niveau d'endotoxine
    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
    Biological Activity Comment
    NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.
    Top Product
    Discover our top product CLCF1 Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Restrictions
    For Research Use only
  • Buffer
    Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
    Conseil sur la manipulation
    Resuspend the protein in the desired concentration in proper buffer
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))
    Autre désignation
    Clcf1 (CLCF1 Produits)
    Synonymes
    clc Protein, nr6 Protein, bsf3 Protein, nnt1 Protein, ciss2 Protein, CLCF1 Protein, BSF-3 Protein, BSF3 Protein, CISS2 Protein, CLC Protein, NNT-1 Protein, NNT1 Protein, NR6 Protein, Bsf3 Protein, Clc Protein, cardiotrophin like cytokine factor 1 Protein, cardiotrophin-like cytokine factor 1 Protein, clcf1 Protein, CLCF1 Protein, Clcf1 Protein
    Sujet
    This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
    Poids moléculaire
    22.4 kDa
    NCBI Accession
    NP_037378
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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