PRKG1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2713946

Détail du produit

Antigène: PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PRKG1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human CGK1 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Autre désignation: Cgk1 (PRKG1 Produits)

Synonymes: prkg1 Protein, zgc:63955 Protein, Pkgi Protein, cGk1 Protein, 1 Protein, PKG Protein, PRKG1B Protein, PRKGR1B Protein, cGK Protein, cGK 1 Protein, cGK1 Protein, cGKI Protein, cGKI-BETA Protein, cGKI-alpha Protein, CGKI Protein, cGKI-beta Protein, AW125416 Protein, Gm19690 Protein, Prkg1b Protein, Prkgr1b Protein, Prkg1beta Protein, protein kinase, cGMP-dependent, type Ia Protein, protein kinase, cGMP-dependent, type I Protein, protein kinase, cGMP-dependent, type 1 Protein, prkg1a Protein, PRKG1 Protein, prkg1 Protein, Prkg1 Protein

Sujet: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Poids moléculaire: 77.6 kDa

NCBI Accession: NP_006249