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ABCC8 Protein (Myc-DYKDDDDK Tag)

ABCC8 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2714263
  • Antigène Voir toutes ABCC8 Protéines
    ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
    Type de proteíne
    Recombinant
    Origine
    Humain
    Source
    • 4
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette ABCC8 protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human ABCC8 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product ABCC8 Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
    Autre désignation
    Abcc8 (ABCC8 Produits)
    Synonymes
    ABC36 Protein, HHF1 Protein, HI Protein, HRINS Protein, MRP8 Protein, PHHI Protein, SUR Protein, SUR1 Protein, SUR1delta2 Protein, TNDM2 Protein, D930031B21Rik Protein, Sur Protein, Sur1 Protein, ATP binding cassette subfamily C member 8 Protein, ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Protein, ABCC8 Protein, Abcc8 Protein
    Sujet
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.
    Poids moléculaire
    176.8 kDa
    NCBI Accession
    NP_000343
    Pathways
    Negative Regulation of Hormone Secretion
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