CRYAB Protéine

N° du produit ABIN2714622

Détail du produit

Antigène: CRYAB (Crystallin, alpha B (CRYAB))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Alpha-crystallin B chain / CRYA2 protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Pureté: > 95 % as determined by SDS-PAGE and Coomassie blue staining

niveau d'endotoxine: < 0.1 EU per μg protein as determined by LAL test

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Restrictions: For Research Use only

Stockage

Buffer: Lyophilized from a 0.2 μM filtered solution of 20 mM Phosphate buffer, 150 mM NaCl, pH 7.2. Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: CRYAB (Crystallin, alpha B (CRYAB))

Autre désignation: alpha-Crystallin B Chain (CRYAB Produits)

Synonymes: CMD1II Protein, CRYA2 Protein, CTPP2 Protein, CTRCT16 Protein, HSPB5 Protein, MFM2 Protein, Crya-2 Protein, Crya2 Protein, HspB5 Protein, AACRYA Protein, CRYAB Protein, cryab Protein, cryab2 Protein, wu:fe37f08 Protein, zgc:91937 Protein, crystallin alpha B Protein, crystallin, alpha B Protein, hypothetical protein Protein, crystallin, alpha B, a Protein, crystallin, alpha B, b Protein, CRYAB Protein, Cryab Protein, ZK1128.7 Protein, cryaba Protein, cryabb Protein

Sujet: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 21.2 kDa

NCBI Accession: NP_001876