FE65 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2714775

Détail du produit

Antigène: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette FE65 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human APBB1 / FE65 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Autre désignation: Apbb1,fe65 (APBB1 Produits)

Synonymes: FE65 Protein, MGC:9072 Protein, RIR Protein, apbb1 Protein, MGC80654 Protein, Fe65 Protein, Rir Protein, amyloid beta precursor protein binding family B member 1 Protein, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog Protein, amyloid beta (A4) precursor protein-binding, family B, member 1 Protein, APBB1 Protein, apbb1.L Protein, Apbb1 Protein

Sujet: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer&aposs disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product&aposs nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer&aposs disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Poids moléculaire: 77.1 kDa

NCBI Accession: NP_001155

Pathways: Positive Regulation of Response to DNA Damage Stimulus