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APPL2 Protein (Myc-DYKDDDDK Tag)

APPL2 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2714848
  • Antigène Voir toutes APPL2 Protéines
    APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
    Type de proteíne
    Recombinant
    Origine
    • 4
    • 1
    Humain
    Source
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette APPL2 protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human APPL2 / DIP13B protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product APPL2 Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
    Autre désignation
    Appl2,dip13b (APPL2 Produits)
    Synonymes
    RGD1563028 Protein, MGC84621 Protein, dip13b Protein, APPL2 Protein, DIP13B Protein, Dip3b Protein, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 Protein, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog Protein, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 Protein, Appl2 Protein, APPL2 Protein, appl2.L Protein, appl2 Protein
    Sujet
    The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(1222)(q24.1q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
    Poids moléculaire
    74.3 kDa
    NCBI Accession
    NP_060641
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