Antizyme Inhibitor 1 Protein (AZIN1) (DYKDDDDK Tag)

N° du produit ABIN2715096

Détail du produit

Antigène: Antizyme Inhibitor 1 (AZIN1)

Type de proteíne: Recombinant

Origine: Humain

Source: Insect cells (Sf9)

Purification/Conjugué: Cette Antizyme Inhibitor 1 protéine est marqué à la DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human AZIN1 (full length, C-term DDK tag, transcript variant 1) protein expressed in Sf9 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: Antizyme Inhibitor 1 (AZIN1)

Autre désignation: Azin1 (AZIN1 Produits)

Synonymes: OAZI Protein, OAZIN Protein, ODC1L Protein, 1700085L02Rik Protein, AI414949 Protein, Oazi Protein, Oazin Protein, AZIN1 Protein, azin1 Protein, oazin Protein, wu:fj32d12 Protein, MGC81852 Protein, wu:fc93f10 Protein, zgc:110131 Protein, antizyme inhibitor 1 Protein, antizyme inhibitor 1b Protein, antizyme inhibitor 1 L homeolog Protein, antizyme inhibitor 1a Protein, AZIN1 Protein, Azin1 Protein, azin1b Protein, azin1.L Protein, azin1 Protein, azin1a Protein

Sujet: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene.

Poids moléculaire: 49.4 kDa

NCBI Accession: NP_056962