DENND1B Protein (His tag)

N° du produit ABIN2719383

Détail du produit

Antigène: DENND1B (DENN/MADD Domain Containing 1B (DENND1B))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette DENND1B protéine est marqué à la His tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human DENND1B (full length, N-term HIS tag, transcript variant 2) protein expressed in E.coli.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: DENND1B (DENN/MADD Domain Containing 1B (DENND1B))

Autre désignation: Dennd1b (DENND1B Produits)

Synonymes: C1ORF18 Protein, C1orf218 Protein, FAM31B Protein, 4632404N19Rik Protein, 4930467M19Rik Protein, 6820401H01Rik Protein, F730008N07Rik Protein, Fam31b Protein, si:ch211-195i21.1 Protein, DENN domain containing 1B Protein, DENN/MADD domain containing 1B Protein, DENND1B Protein, dennd1b Protein, Dennd1b Protein

Sujet: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2 see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010].

Poids moléculaire: 44.8 kDa

NCBI Accession: NP_659414