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ERCC1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

ERCC1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2720416
  • Antigène Voir toutes ERCC1 Protéines
    ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
    Type de proteíne
    Recombinant
    Attributs du protein
    Transcript Variant 2
    Origine
    • 7
    • 1
    • 1
    • 1
    Humain
    Source
    • 3
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette ERCC1 protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human ERCC1 (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product ERCC1 Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
    Autre désignation
    Ercc1 (ERCC1 Produits)
    Synonymes
    COFS4 Protein, RAD10 Protein, UV20 Protein, Ercc-1 Protein, ercc1 Protein, T12H1.18 Protein, T12H1_18 Protein, UV REPAIR DEFICIENT 7 Protein, UVR7 Protein, ERCC excision repair 1, endonuclease non-catalytic subunit Protein, excision repair cross-complementing rodent repair deficiency, complementation group 1 Protein, DNA excision repair protein ERCC-1 Protein, nucleotide repair protein Protein, excision repair cross-complementation group 1 L homeolog Protein, excision repair cross-complementation group 1 Protein, ERCC1 Protein, Ercc1 Protein, CC1G_04546 Protein, CpipJ_CPIJ013903 Protein, PITG_13719 Protein, ercc1 Protein, ercc1.L Protein
    Sujet
    The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
    Poids moléculaire
    32.4 kDa
    NCBI Accession
    NP_001974
    Pathways
    Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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