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Geminin Protein (Myc-DYKDDDDK Tag)

GMNN Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2721810
  • Antigène Voir toutes Geminin (GMNN) Protéines
    Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))
    Type de proteíne
    Recombinant
    Origine
    • 4
    • 2
    • 1
    Humain
    Source
    • 5
    • 2
    HEK-293 Cells
    Purification/Conjugué
    Cette Geminin protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human Geminin protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product GMNN Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))
    Autre désignation
    Geminin (GMNN Produits)
    Synonymes
    CG3183 Protein, Dm Geminin Protein, Dm geminin Protein, Dmel\\CG3183 Protein, Gem Protein, Geminin Protein, anon-WO0257455.1 Protein, gem Protein, l(2)k14019 Protein, v(2)k09107 Protein, sb:cb254 Protein, zgc:66217 Protein, GB16871 Protein, GMNN Protein, geminin Protein, dyak_GLEANR_833 Protein, DyakGE24654 Protein, GE24654 Protein, LOC100049517 Protein, AW546347 Protein, geminin, DNA replication inhibitor Protein, CG3183 gene product from transcript CG3183-RA Protein, geminin Protein, GE24654 gene product from transcript GE24654-RA Protein, GMNN Protein, geminin Protein, gmnn Protein, LOC410093 Protein, Dyak\geminin Protein, Gmnn Protein
    Sujet
    This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
    Poids moléculaire
    23.4 kDa
    NCBI Accession
    NP_056979
    Pathways
    EGFR Signaling Pathway, DNA Replication
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