GRB2 Protein (Transcript Variant 1) (His tag)

N° du produit ABIN2722230

Détail du produit

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GRB2 protéine est marqué à la His tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human GRB2 / ASH (transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Pureté: > 95 % as determined by SDS-PAGE and Coomassie blue staining

niveau d'endotoxine: < 0.1 EU per μg protein as determined by LAL test

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Buffer: Lyophilized from a 0.2 μM filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0. Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Autre désignation: Grb2,ash (GRB2 Produits)

Synonymes: GRB2 Protein, grb2 Protein, AA408164 Protein, Ash Protein, ASH Protein, EGFRBP-GRB2 Protein, Grb3-3 Protein, MST084 Protein, MSTP084 Protein, NCKAP2 Protein, wu:fb18e12 Protein, wu:fb34e06 Protein, zgc:73077 Protein, growth factor receptor bound protein 2 Protein, growth factor receptor-bound protein 2 Protein, growth factor receptor-bound protein 2b Protein, GRB2 Protein, grb2 Protein, Grb2 Protein, grb2b Protein

Sujet: Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. [UniProtKB/Swiss-Prot Function]

Poids moléculaire: 26.3 kDa

NCBI Accession: NP_002077

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation