HDAC4 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2722509

Détail du produit

Antigène: HDAC4 (Histone Deacetylase 4 (HDAC4))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette HDAC4 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human HDAC4 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Référence

Yang, Li, Chen, Yuan, Dong, Zhang, Wu, Wang: "PARP-1 mediates LPS-induced HMGB1 release by macrophages through regulation of HMGB1 acetylation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 12, pp. 6114-23, (2014) (PubMed).

Détail du antigène

Antigène: HDAC4 (Histone Deacetylase 4 (HDAC4))

Autre désignation: Hdac4 (HDAC4 Produits)

Synonymes: CG1770 Protein, DHDAC4 Protein, Dmel\\CG1770 Protein, GC1770 Protein, HDAC Protein, HDAC4a Protein, dHDAC4 Protein, dmHDA405 Protein, hdac4 Protein, dana_GLEANR_19966 Protein, DanaGF18710 Protein, GF18710 Protein, HDAC4 Protein, AHO3 Protein, BDMR Protein, HA6116 Protein, HD4 Protein, HDAC-4 Protein, HDAC-A Protein, HDACA Protein, 4932408F19Rik Protein, AI047285 Protein, wu:fa96d08 Protein, wu:fc56f08 Protein, zgc:152701 Protein, histone deacetylase 4 Protein, hypothetical protein Protein, Histone deacetylase 4 Protein, GF18710 gene product from transcript GF18710-RC Protein, PTRG_03699 Protein, PGTG_15512 Protein, HDAC4 Protein, Dana\GF18710 Protein, Hdac4 Protein, hdac4 Protein

Sujet: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Poids moléculaire: 118.9 kDa

NCBI Accession: NP_006028

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process