IKZF1 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2723364

Détail du produit

Antigène: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IKZF1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human IKZF1 / IKAROS protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Autre désignation: Ikzf1,ikaros (IKZF1 Produits)

Synonymes: Hs.54452 Protein, IK1 Protein, IKAROS Protein, LYF1 Protein, PRO0758 Protein, ZNFN1A1 Protein, hIk-1 Protein, RGD1562979 Protein, ikaros Protein, znfn1a1 Protein, ik1 Protein, lyf1 Protein, hik-1 Protein, pro0758 Protein, hs.54452 Protein, MGC108252 Protein, 5832432G11Rik Protein, Ikaros Protein, LyF-1 Protein, Zfpn1a1 Protein, Znfn1a1 Protein, hlk-1 Protein, mKIAA4227 Protein, ikzf1 Protein, IKAROS family zinc finger 1 Protein, IKAROS family zinc finger 1 (Ikaros) Protein, IKZF1 Protein, Ikzf1 Protein, ikzf1 Protein

Sujet: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Poids moléculaire: 57.3 kDa

NCBI Accession: NP_006051

Pathways: Production of Molecular Mediator of Immune Response