IMPA1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes IMPA1 Protéines
- IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 1
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette IMPA1 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human Inositol monophosphatase / IMPA1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product IMPA1 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))
- Autre désignation
- Inositol Monophosphatase,impa1 (IMPA1 Produits)
- Synonymes
- zgc:100926 Protein, 2610002K09Rik Protein, 2900059K10Rik Protein, AI325909 Protein, IMP Protein, IMPA Protein, impa Protein, inositol monophosphatase 1 Protein, inositol(myo)-1(or 4)-monophosphatase 1 Protein, inositol (myo)-1(or 4)-monophosphatase 1 Protein, inositol monophosphatase Protein, inositol(myo)-1(or 4)-monophosphatase 1 S homeolog Protein, impa1 Protein, Impa1 Protein, IMPA1 Protein, impa1.S Protein
- Sujet
- This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2&apos-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
- Poids moléculaire
- 30 kDa
- NCBI Accession
- NP_005527
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