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MBNL1 Protein (Transcript Variant 6) (Myc-DYKDDDDK Tag)

MBNL1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD, Func, PI Active
N° du produit ABIN2725584
  • Antigène Voir toutes MBNL1 Protéines
    MBNL1 (Muscleblind-like Protein 1 (MBNL1))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    Transcript Variant 6
    Origine
    • 8
    • 1
    Humain
    Source
    • 4
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette MBNL1 protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD), Functional Studies (Func), Protein Interaction (PI)
    Specificité
    Optimal preservation of protein structure, post-translational modifications and functions.
    Attributs du produit
    • Recombinant human MBNL1 (transcript variant 6) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Biological Activity Comment
    MBNL1 Activity Verified in an mRNA Splicing Assay:,MBNL1 Activity Verified in an mRNA Splicing Assay:
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    > 50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Echeverria, Cooper: "Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron." dans: Nucleic acids research, Vol. 42, Issue 3, pp. 1893-903, (2014) (PubMed).

  • Antigène
    MBNL1 (Muscleblind-like Protein 1 (MBNL1))
    Autre désignation
    Mbnl1 (MBNL1 Produits)
    Synonymes
    MBNL1 Protein, zgc:153954 Protein, Mbnl Protein, mKIAA0428 Protein, EXP Protein, EXP35 Protein, EXP40 Protein, EXP42 Protein, MBNL Protein, muscleblind like splicing regulator 1 Protein, muscleblind-like splicing regulator 1 Protein, muscleblind like splicing factor 1 Protein, MBNL1 Protein, mbnl1 Protein, Mbnl1 Protein
    Sujet
    This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
    Poids moléculaire
    36.8 kDa
    NCBI Accession
    NP_997179
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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