MIB1 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2725966

Détail du produit

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette MIB1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human MIB1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Référence

Kwon, Dimitriadi, Terzic, Cable, Hart, Chitnis, Fischbeck, Burnett: "The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein." dans: Molecular biology of the cell, Vol. 24, Issue 12, pp. 1863-71, (2013) (PubMed).

Détail du antigène

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Autre désignation: Mib1 (MIB1 Produits)

Synonymes: DIP-1 Protein, DIP1 Protein, LVNC7 Protein, MIB Protein, ZZANK2 Protein, ZZZ6 Protein, E430019M12Rik Protein, Mib Protein, mKIAA1323 Protein, dip-1 Protein, mib Protein, mindbomb Protein, cg5841 Protein, chunp6889 Protein, fe47f05 Protein, im:7148100 Protein, mib1 Protein, wu:fe47f05 Protein, CG5841 Protein, D-mib Protein, D-mib1 Protein, Dmel\CG5841 Protein, Dmib Protein, MIB1 Protein, Mib1 Protein, dmib1 Protein, l(3)72CDa Protein, l(3)72Db Protein, mib1/2 Protein, mind-bomb Protein, mindbomb E3 ubiquitin protein ligase 1 Protein, mindbomb E3 ubiquitin protein ligase 1 L homeolog Protein, mind bomb 1 Protein, MIB1 Protein, Mib1 Protein, mib1.L Protein, mib1 Protein

Sujet: This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1).

Poids moléculaire: 110 kDa

NCBI Accession: NP_065825

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2