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NCF4 Protein (His tag)

NCF4 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2726891
  • Antigène Voir toutes NCF4 Protéines
    NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
    Type de proteíne
    Recombinant
    Origine
    • 5
    • 2
    Humain
    Source
    • 4
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette NCF4 protéine est marqué à la His tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human NCF-4 (full length, N-term HIS tag, transcript variant 1) protein expressed in E.coli.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product NCF4 Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the N-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
    Autre désignation
    Ncf-4 (NCF4 Produits)
    Synonymes
    p40phox Protein, AI451400 Protein, NCF Protein, P40PHOX Protein, SH3PXD4 Protein, neutrophil cytosolic factor 4 Protein, ncf4 Protein, Ncf4 Protein, NCF4 Protein
    Sujet
    The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
    Poids moléculaire
    38.9 kDa
    NCBI Accession
    NP_000622
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