DCC Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2727109

Détail du produit

Antigène: DCC (Deleted in Colorectal Carcinoma (DCC))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette DCC protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Netrin receptor DCC protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: DCC (Deleted in Colorectal Carcinoma (DCC))

Autre désignation: Netrin Receptor Dcc (DCC Produits)

Synonymes: CRC18 Protein, CRCR1 Protein, IGDCC1 Protein, MRMV1 Protein, DCC Protein, zdcc Protein, C030036D22Rik Protein, Igdcc1 Protein, xdcc Protein, XDCCa Protein, dcca-A Protein, Dcc Protein, DCC netrin 1 receptor Protein, deleted in colorectal carcinoma Protein, netrin receptor DCC Protein, DCC Protein, dcc Protein, Dcc Protein, LOC100712666 Protein

Sujet: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Poids moléculaire: 158.3 kDa

NCBI Accession: NP_005206

Pathways: Regulation of Cell Size