NLRP10 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2727387

Détail du produit

Antigène: NLRP10 (NLR Family, Pyrin Domain Containing 10 (NLRP10))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NLRP10 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human NLRP10 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Référence

Murphy, Grehan, Lynch: "Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10." dans: Neuromolecular medicine, Vol. 16, Issue 1, pp. 205-15, (2014) (PubMed).

Détail du antigène

Antigène: NLRP10 (NLR Family, Pyrin Domain Containing 10 (NLRP10))

Autre désignation: Nlrp10 (NLRP10 Produits)

Synonymes: CLR11.1 Protein, NALP10 Protein, NOD8 Protein, PAN5 Protein, PYNOD Protein, 6430548I20Rik Protein, Nalp10 Protein, Napl10 Protein, Pynod Protein, NLR family pyrin domain containing 10 Protein, NLR family, pyrin domain containing 10 Protein, NLRP10 Protein, Nlrp10 Protein

Sujet: Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.

Poids moléculaire: 74.9 kDa

NCBI Accession: NP_789791

Pathways: Inflammasome