NR1I3 Protein (His tag)

N° du produit ABIN2727555

Détail du produit

Antigène: NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette NR1I3 protéine est marqué à la His tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human NR1I3 (full length, N-term HIS tag, transcript variant 1) protein expressed in E.coli.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

Autre désignation: Nr1i3 (NR1I3 Produits)

Synonymes: AA209988 Protein, AI551208 Protein, CAR Protein, CAR-beta Protein, Care2 Protein, ESTM32 Protein, MB67 Protein, CAR1 Protein, CXR Protein, nuclear receptor subfamily 1 group I member 3 Protein, nuclear receptor subfamily 1, group I, member 3 Protein, NR1I3 Protein, Nr1i3 Protein

Sujet: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 40.3 kDa

NCBI Accession: NP_001070950

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway