PAK7 Protein (Transcript Variant 2)

N° du produit ABIN2728183

Détail du produit

Antigène: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Functional Studies (Func), Antibody Production (AbP), Standard (STD), Protein Interaction (PI)

Specificité: Optimal preservation of protein structure, post-translational modifications and functions.

Attributs du produit:

• Recombinant human PAK7 / PAK5 (transcript variant 2) protein expressed in E. coli.
• Produced with end-sequenced ORF clone
• Tested for bioactivity.

Pureté: > 90 % as determined by SDS-PAGE and Coomassie blue staining

niveau d'endotoxine: <0.1 ng/μg of protein (<1EU/μg).

Biological Activity Comment: Specific activity was determined as 4,199 pmoles/min/μg, according to the Zlyte assay protocol

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10 % glycerol, 5 mM DTT.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Autre désignation: Pak7,pak5 (PAK7 Produits)

Synonymes: PAK5 Protein, pak5 Protein, 2900083L08Rik Protein, 6430627N20 Protein, Pak5 Protein, PAK-5 Protein, PAK-7 Protein, p21 (RAC1) activated kinase 5 Protein, p21 (RAC1) activated kinase 5 L homeolog Protein, p21 protein (Cdc42/Rac)-activated kinase 7 Protein, p21 (RAC1) activated kinase 7 Protein, PAK5 Protein, pak5.L Protein, Pak7 Protein

Sujet: The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.

Poids moléculaire: 33.9 kda

NCBI Accession: NP_817127