PARN Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2728260

Détail du produit

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PARN protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PARN (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Autre désignation: Parn (PARN Produits)

Synonymes: parn-A Protein, xparn Protein, DAN Protein, RGD1565449 Protein, zgc:56067 Protein, 1200003I18Rik Protein, poly(A)-specific ribonuclease L homeolog Protein, poly(A)-specific ribonuclease Protein, poly(A)-specific ribonuclease (deadenylation nuclease) Protein, parn.L Protein, PARN Protein, Parn Protein, parn Protein

Sujet: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 73.3 kDa

NCBI Accession: NP_002573