PFKFB3 Protein (His tag)

N° du produit ABIN2728749

Détail du produit

Antigène: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PFKFB3 protéine est marqué à la His tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PFKFB3 (full length, N-term HIS tag, transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 50 mM Tris,8M Urea, pH 8.0.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Autre désignation: Pfkfb3 (PFKFB3 Produits)

Synonymes: IPFK2 Protein, PFK2 Protein, E330010H22Rik Protein, iPFK-2 Protein, uPFK-2 Protein, PFKFB3 Protein, zgc:73257 Protein, wu:fc31e01 Protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog Protein, PFKFB3 Protein, Pfkfb3 Protein, pfkfb3.S Protein, pfkfb3 Protein, PTRG_09894 Protein, Tsp_06710 Protein

Sujet: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 59.4 kDa

NCBI Accession: NP_004557

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process