PIKFYVE Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)

N° du produit ABIN2729012

Détail du produit

Antigène: PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 4

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PIKFYVE protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PIP5K3 (transcript variant 4) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))

Autre désignation: Pip5k3 (PIKFYVE Produits)

Synonymes: pip5k3 Protein, wu:fo93c03 Protein, PIP5K3 Protein, fab1-like Protein, CFD Protein, FAB1 Protein, PIP5K Protein, ZFYVE29 Protein, 5230400C17Rik Protein, Pip5k Protein, Pip5k3 Protein, Pipk5k3 Protein, PipkIII Protein, p235 Protein, phosphoinositide kinase, FYVE finger containing Protein, phosphoinositide kinase, FYVE-type zinc finger containing Protein, phosphoinositide kinase, FYVE type zinc finger containing Protein, pikfyve Protein, PIKFYVE Protein, Pikfyve Protein

Sujet: Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD) an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010].

Poids moléculaire: 62

NCBI Accession: NP_001171471

Pathways: Inositol Metabolic Process