PML Protein (Transcript Variant 5) (Myc-DYKDDDDK Tag)

N° du produit ABIN2729209

Détail du produit

Antigène: PML (Promyelocytic Leukemia (PML))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 5

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PML protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PML / RNF71 (transcript variant 5) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PML (Promyelocytic Leukemia (PML))

Autre désignation: Pml,rnf71 (PML Produits)

Synonymes: MYL Protein, PP8675 Protein, RNF71 Protein, TRIM19 Protein, 1200009E24Rik Protein, AI661194 Protein, Trim19 Protein, RGD1562602 Protein, PML Protein, promyelocytic leukemia Protein, PML Protein, Pml Protein

Sujet: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: 61.8 kDa

NCBI Accession: NP_150247

Pathways: Signalisation p53, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus