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POLH Protein (Myc-DYKDDDDK Tag)

POLH Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2729308
  • Antigène Voir toutes POLH Protéines
    POLH (Polymerase (DNA Directed), eta (POLH))
    Type de proteíne
    Recombinant
    Origine
    • 2
    • 1
    • 1
    Humain
    Source
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette POLH protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human POLH / RAD30 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product POLH Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    POLH (Polymerase (DNA Directed), eta (POLH))
    Autre désignation
    Polh,rad30 (POLH Produits)
    Synonymes
    POLH Protein, fc50a12 Protein, wu:fc50a12 Protein, zgc:136881 Protein, zgc:152642 Protein, RAD30 Protein, RAD30A Protein, XP-V Protein, XPV Protein, polymerase (DNA directed), eta S homeolog Protein, DNA polymerase eta Protein, polymerase (DNA directed), eta Protein, putative DNA polymerase eta Protein, polymerase (DNA directed), eta (RAD 30 related) Protein, polh.S Protein, POLH Protein, polh Protein, Tb10.70.6190 Protein, LINJ_21_0690 Protein, Polh Protein, LOC100443019 Protein
    Sujet
    This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
    Poids moléculaire
    78.2 kDa
    NCBI Accession
    NP_006493
    Pathways
    Réparation de l'ADN
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