POT1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes POT1 Protéines
- POT1 (Protection of Telomeres 1 (POT1))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 1
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette POT1 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human POT1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product POT1 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity." dans: PLoS ONE, Vol. 11, Issue 5, pp. e0156378, (2016) (PubMed).
: "The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs." dans: Biochimie, Vol. 115, pp. 17-27, (2015) (PubMed).
: "
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An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity." dans: PLoS ONE, Vol. 11, Issue 5, pp. e0156378, (2016) (PubMed).
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- Antigène
- POT1 (Protection of Telomeres 1 (POT1))
- Autre désignation
- Pot1 (POT1 Produits)
- Synonymes
- HPOT1 Protein, POT1 Protein, DKFZp469P1825 Protein, pot1 Protein, 1500031H18Rik Protein, AI851169 Protein, Pot1 Protein, Pot1a Protein, protection of telomeres 1 Protein, protection of telomeres 1 L homeolog Protein, protection of telomeres 1A Protein, POT1 Protein, pot1.L Protein, Pot1a Protein, Pot1 Protein
- Sujet
- This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
- Poids moléculaire
- 71.3 kDa
- NCBI Accession
- NP_056265
- Pathways
- Cycle Cellulaire, Telomere Maintenance
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