PKC iota Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2729628

Détail du produit

Antigène: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PKC iota protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PRKCI protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Autre désignation: Prkci (PRKCI Produits)

Synonymes: DXS1179E Protein, PKCI Protein, nPKC-iota Protein, aPKC[l] Protein, hal Protein, has Protein, PRKCI Protein, PKC Protein, 2310021H13Rik Protein, AI427505 Protein, PKClambda Protein, Pkci Protein, Pkcl Protein, Prkcl Protein, aPKClambda Protein, mKIAA4165 Protein, protein kinase C iota Protein, protein kinase C, iota Protein, PRKCI Protein, prkci Protein, Prkci Protein

Sujet: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Poids moléculaire: 68.1 kDa

NCBI Accession: NP_002731

Pathways: Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation