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RASA1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

RASA1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2730523
  • Antigène Voir toutes RASA1 Protéines
    RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
    Type de proteíne
    Recombinant
    Attributs du protein
    Transcript Variant 1
    Origine
    Humain
    Source
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette RASA1 protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human RASA1 / RasGAP (transcript variant 1) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product RASA1 Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
    Autre désignation
    Rasa1,rasgap (RASA1 Produits)
    Synonymes
    CG9209 Protein, D-RasGAP Protein, Dmel\\CG9209 Protein, RAS-GAP Protein, RasGAP Protein, RasGap Protein, rasGap Protein, CM-AVM Protein, CMAVM Protein, GAP Protein, PKWS Protein, RASA Protein, RASGAP Protein, p120GAP Protein, p120RASGAP Protein, GAPX Protein, Rasa Protein, Gap Protein, vacuolar peduncle Protein, RAS p21 protein activator 1 Protein, vap Protein, RASA1 Protein, Rasa1 Protein
    Sujet
    The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
    Poids moléculaire
    116.2 kDa
    NCBI Accession
    NP_002881
    Pathways
    Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals
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