UHRF1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2735000

Détail du produit

Antigène: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette UHRF1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human UHRF1 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Autre désignation: Uhrf1 (UHRF1 Produits)

Synonymes: ICBP90 Protein, Np95 Protein, RNF106 Protein, hNP95 Protein, hUHRF1 Protein, AL022808 Protein, NP95 Protein, fb97f09 Protein, wu:fb97f09 Protein, zgc:63539 Protein, UHRF1 Protein, ubiquitin like with PHD and ring finger domains 1 Protein, ubiquitin-like, containing PHD and RING finger domains, 1 Protein, ubiquitin-like with PHD and ring finger domains 1 Protein, UHRF1 Protein, Uhrf1 Protein, uhrf1 Protein

Sujet: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

Poids moléculaire: 90.9 kDa

NCBI Accession: NP_037414