UPF3B Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2735037

Détail du produit

Antigène: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette UPF3B protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human UPF3B / RENT3B (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Autre désignation: Upf3b,rent3b (UPF3B Produits)

Synonymes: HUPF3B Protein, MRXS14 Protein, RENT3B Protein, UPF3X Protein, 5730594O13Rik Protein, AI317193 Protein, AW541158 Protein, RGD1560264 Protein, UPF3B, regulator of nonsense mediated mRNA decay Protein, UPF3 regulator of nonsense transcripts homolog B (yeast) Protein, UPF3B Protein, Upf3b Protein

Sujet: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Poids moléculaire: 56 kDa

NCBI Accession: NP_075386