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CD51/CD61 Protein (AA 31-992) (His tag)

ITGAV/ITGB3 Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN2870663
  • Antigène Voir toutes CD51/CD61 (ITGAV/ITGB3) Protéines
    CD51/CD61 (ITGAV/ITGB3) (Integrin AlphaV, Integrin Beta3 (ITGAV/ITGB3))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 31-992
    Origine
    • 3
    • 3
    • 1
    • 1
    Humain
    Source
    • 8
    HEK-293 Cells
    Purification/Conjugué
    Cette CD51/CD61 protéine est marqué à la His tag.
    Séquence
    AA 31-992
    Attributs du produit
    Human ITGAV & ITGB3 Heterodimer Protein, produced by co-expression of ITGAV and ITGB3, has a calculated MW of 113 kDa (ITGAV) and 81.8 kDa (ITGB3). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 27 (ITGB3). The reducing (R) protein migrates as 145 kDa (ITGAV) and 100-116 kDa (ITGB3) respectively due to glycosylation.
    Pureté
    >95 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product ITGAV/ITGB3 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 150 mM NaCl, pH 7.5
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
  • Kondo, Wakamori, Hirata, Temma: "Radioiodinated bicyclic RGD peptide for imaging integrin αvβ3 in cancers." dans: Biochemical and biophysical research communications, Vol. 528, Issue 1, pp. 168-173, (2021) (PubMed).

  • Antigène
    CD51/CD61 (ITGAV/ITGB3) (Integrin AlphaV, Integrin Beta3 (ITGAV/ITGB3))
    Autre désignation
    Integrin alpha V beta 3 (ITGAV/ITGB3 Produits)
    Synonymes
    CD51 Protein, MSK8 Protein, VNRA Protein, VTNR Protein, integrin subunit alpha V Protein, ITGAV Protein
    Sujet
    Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    Poids moléculaire
    112.9 kDa (ITGAV) & 81.8 kDa (ITGB3)
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