ITGAV/ITGB6 Protein (AA 31-992) (His tag)
-
- Antigène Tous les produits ITGAV/ITGB6
- ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 31-992
-
Origine
- Humain
-
Source
- HEK-293 Cells
- Purification/Conjugué
- Cette ITGAV/ITGB6 protéine est marqué à la His tag.
- Séquence
- AA 31-992
- Attributs du produit
- Human ITGAV & ITGB6 Heterodimer Protein, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 113 kDa (ITGAV) and 79.6 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The reducing (R) protein migrates as 145 kDa (ITGAV) and 115 kDa (ITGB6) respectively due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
-
Integrin AlphaV Beta6 (ITGAV/ITGB6) (AA 31-988) protein (His tag)
ITGAV/ITGB6 Origine: Souris Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin AlphaV Beta6 (ITGAV/ITGB6) (AA 31-993) protein (His tag)ITGAV/ITGB6 Origine: Macaque rhésus Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin AlphaV Beta6 (ITGAV/ITGB6) (AA 31-992) (Active) protein (His tag,AVI tag,Biotin)ITGAV/ITGB6 Origine: Humain Hôte: HEK-293 Cells Recombinant >90 % as determined by reduced SDS-PAGE. Active
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
-
- Antigène
- ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))
- Autre désignation
- Integrin alpha V beta 6 (ITGAV/ITGB6 Produits)
- Sujet
- Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency-associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
- Poids moléculaire
- 112.9 kDa (ITGAV) & 79.6 kDa (ITGB6)
-
