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CD38 Protein (AA 43-300) (His tag,AVI tag,Biotin)

Origine: Humain Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
N° du produit ABIN3137679
  • Antigène Voir toutes CD38 Protéines
    CD38
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 43-300
    Origine
    • 24
    • 10
    • 5
    • 3
    • 1
    Humain
    Source
    • 17
    • 8
    • 7
    • 5
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette CD38 protéine est marqué à la His tag,AVI tag,Biotin.
    Séquence
    AA 43-300
    Specificité
    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
    Attributs du produit
    This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 32.5 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Pureté
    >90 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD38 Protéine
  • Commentaires

    Ready-to-use AvitagTM biotinylated protein:
    The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

    This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
  • Antigène
    CD38
    Abstract
    CD38 Produits
    Synonymes
    T10 Protein, Cd38-rs1 Protein, cd38 Protein, ADPRC 1 Protein, cADPr hydrolase 1 Protein, CD38 molecule Protein, CD38 antigen Protein, CD38 molecule L homeolog Protein, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Protein, CD38 Protein, Cd38 Protein, cd38.L Protein
    Sujet
    CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
    Poids moléculaire
    32.5 kDa
    NCBI Accession
    NP_001766
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