Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 1-125), (Extracellular Domain) (Active) protein (Fc Tag,His tag)

Détails pour le produit réf. ABIN3218780
Nom de la protéine
  • AAT5
  • ACVRLK4
  • ALK-5
  • ALK5
  • LDS1A
  • LDS2A
  • MSSE
  • SKR4
  • TGFR-1
  • aat5
  • acvrlk4
  • alk-5
  • alk5
  • lds1a
  • lds2a
  • skr4
  • tgfr-1
  • TGFBR1
  • x-trr1
  • AU017191
  • Alk-5
  • TbetaR-I
  • TbetaRI
  • Alk5
  • Skr4
  • Tgfr-1
  • tbetaR-I
  • tgfbr1
  • zgc:123263
  • transforming growth factor beta receptor 1
  • transforming growth factor beta receptor I
  • transforming growth factor beta receptor I S homeolog
  • transforming growth factor, beta receptor I
  • transforming growth factor, beta receptor 1
  • transforming growth factor, beta receptor 1 a
  • TGFBR1
  • tgfbr1
  • tgfbr1.S
  • Tgfbr1
  • tgfbr1a
Attributs du protein
Extracellular Domain, AA 1-125
2
2
1
1
1
1
1
1
1
1
Origine
Humain
9
4
1
1
Source
Human Cells
7
2
2
2
1
1
Type de proteíne
Recombinant
Activité biologique
Active
Purification/Conjugué
Cette TGFBR1 protéine est marqué à la Fc Tag,His tag.
Application
Functional Studies (Func), SDS-PAGE (SDS)
Options
Attributs du produit The recombinant human TGFBR1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 349 amino acids and has a predicted molecular mass of 38.8 kDa. As a result of glycosylation, the apparent molecular mass of rh TGFBR1/Fc monomer is approximately 45-50 kDa in SDS-PAGE under reducing conditions, with ~10 % free Fc fragments.

Protein Structure: A DNA sequence encoding the human TGFBR1 (NP_004603.1) extracellular domain (Met 1-Glu 125) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Predicted N-Term: Ala 25
Pureté > 85 % as determined by SDS-PAGE
niveau d'endotoxine < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment 1. Measured by its binding ability in a functional ELISA . Immobilized mouse CD105 at 10 μg/ml (100 μl/well) can bind human TGFRB1 with a linear ranger of 6.4-800 ng/ml .
2. Measured by its ability to bind human CD105 in a functional ELISA .
Nom de la protéine
Sujet Synonyms: AAT5,ACVRLK4,ALK-5,ALK5,ESS1,LDS1,LDS1A,LDS2A,MSSE,SKR4,tbetaR-I,TGFR-1
Poids moléculaire 38.8 kDa, 45-50 kDa
NCBI Accession NP_004603
Pathways Growth Factor Binding
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Stock -20 °C,-80 °C
Stockage commentaire Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Date de péremption 12 months
Images (Fournisseur)
 image for Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 1-125), (Extracellular Domain) (Active) protein (Fc Tag,His tag) (ABIN3218780) Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 1-125), (Extracellular Domain) (Active) protein (Fc Tag,His tag)
Background publications Sridurongrit, Larsson, Schwartz, Ruiz-Lozano, Kaartinen: "Signaling via the Tgf-beta type I receptor Alk5 in heart development." dans: Developmental biology, Vol. 322, Issue 1, pp. 208-18, 2008

Sridurongrit, Larsson, Schwartz, Ruiz-Lozano, Kaartinen: "Signaling via the Tgf-beta type I receptor Alk5 in heart development." dans: Developmental biology, Vol. 322, Issue 1, pp. 208-18, 2008 (PubMed).

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