Transforming Growth Factor, beta 1 (TGFB1) (AA 1-390), (full length) (Active) protein (His tag)

Détails pour le produit réf. ABIN3218782
Nom de la protéine
  • CED
  • DPD1
  • LAP
  • TGFB
  • TGFbeta
  • TGF-beta
  • TGF-BETA-1
  • TGF-beta5
  • ced
  • dpd1
  • lap
  • tgf-beta
  • tgfb
  • tgfb5
  • tgfbeta
  • TGF-beta1
  • TGFbeta1
  • Tgfb
  • Tgfb-1
  • ai39657
  • tgfb1
  • wu:fb13a07
  • xx:ai39657
  • TGFB1
  • csd
  • cdb1
  • cdg2
  • csd1
  • csd2
  • csd3
  • ebmd
  • lcd1
  • bigh3
  • cdgg1
  • betaig-h3
  • TGFB4
  • transforming growth factor beta 1
  • transforming growth factor beta-1
  • transforming growth factor beta 1 L homeolog
  • transforming growth factor, beta 1
  • transforming growth factor, beta 1a
  • transforming growth factor beta induced L homeolog
  • TGFB1
  • Tgfb1
  • tgfb1.L
  • tgfb1a
  • tgfbi.L
Attributs du protein
full length, AA 1-390
26
9
5
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Origine
Humain
67
10
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Source
Human Cells
43
14
13
10
9
6
4
3
3
1
Type de proteíne
Recombinant
Activité biologique
Active
Purification/Conjugué
Cette TGFB1 protéine est marqué à la His tag.
Application
Functional Studies (Func), SDS-PAGE (SDS)
Options
Attributs du produit The recombinant human latent TGFβ1 consists of 370 amino acids and has a calculated molecular mass of 42.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh TGFβ1 is approximately 16, 38 and 55 kDa corresponding to mature TGFβ1, LAP protein and inacitve latent TGFβ1 respectively due to glycosylation. In non-reduced SDS-PAGE, it migrates as an approximately 110 kDa protein consisting of a TGFβ1 homodimer non-covalently linked to a LAP homodimer.

Protein Structure: A DNA sequence encoding the full length of human TGFβ1 (NP_000651.3) (Met 1-Ser 390) was fused with a C-terminal polyhistidine tag.
Predicted N-Term: Leu 30 & Ala 279
Pureté > 95 % as determined by SDS-PAGE
niveau d'endotoxine < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment Measured by its ability to bind biotinylated Human ALK1-Fc in functional Elisa.
Nom de la protéine
Sujet Synonyms: CED,DPD1,LAP,TGF-beta 1,TGFB,TGFbeta
Poids moléculaire 42.4 kDa, 55 kDa, 110 kDa
NCBI Accession NP_000651
Pathways EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Stock -20 °C,-80 °C
Stockage commentaire Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Date de péremption 12 months
Images (Fournisseur)
 image for Transforming Growth Factor, beta 1 (TGFB1) (AA 1-390), (full length) (Active) protein (His tag) (ABIN3218782) Transforming Growth Factor, beta 1 (TGFB1) (AA 1-390), (full length) (Active) protein (His tag)
Background publications Vaughn, Broussard, Hall, Scott, Blanton, Milunsky, Hecht: "Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region." dans: Genomics, Vol. 66, Issue 1, pp. 119-21, 2000

Vaughn, Broussard, Hall, Scott, Blanton, Milunsky, Hecht: "Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region." dans: Genomics, Vol. 66, Issue 1, pp. 119-21, 2000 (PubMed).

Letterio, Roberts: "Regulation of immune responses by TGF-beta." dans: Annual review of immunology, Vol. 16, pp. 137-61, 1998 (PubMed).

Assoian, Komoriya, Meyers, Miller, Sporn: "Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization." dans: The Journal of biological chemistry, Vol. 258, Issue 11, pp. 7155-60, 1983 (PubMed).

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