Activin Receptor Type I (ACRV1) (AA 1-124), (Extracellular Domain) protein (His tag)

Détails pour le produit réf. ABIN3218786
Nom de la protéine
  • ACTRI
  • ACVR1A
  • ACVRLK2
  • ALK2
  • FOP
  • SKR1
  • TSRI
  • ActR-IA
  • ActR-I
  • ActRIA
  • Acvr
  • Acvrlk2
  • Alk-2
  • Alk8
  • D330013D15Rik
  • Tsk7L
  • actri
  • acvr1
  • acvr1-a
  • acvr1-b
  • acvr1a
  • acvrlk2
  • alk-2
  • alk2
  • alk8
  • fop
  • sax
  • skr1
  • tsri
  • xALK-2
  • activin A receptor type 1
  • activin A receptor, type 1
  • activin A receptor type 1 S homeolog
  • ACVR1
  • Acvr1
  • acvr1.S
Attributs du protein
AA 1-124, Extracellular Domain
5
4
2
2
2
1
1
1
1
1
1
1
1
1
Origine
Humain
16
6
2
2
1
1
1
Source
Baculovirus infected Insect Cells
9
7
6
3
2
2
Type de proteíne
Recombinant
Purification/Conjugué
His tag
Application
SDS-PAGE (SDS)
Options
Attributs du produit The secreted recombinant human ALK2 consists of 114 amino acids and has a calculated molecular mass of 12.8KDa. It migrates as an approximately 17 kDa band in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the extracellular domain (Met 1-Val 124) of human ALK2 (Q04771) (Met 1-Val 124) was fused with a polyhistidine tag at the C-terminus.
Predicted N-Term: Met 21
Pureté > 93 % as determined by SDS-PAGE
niveau d'endotoxine < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment Kinase activity untested
Nom de la protéine
Sujet Synonyms: ACTRI,ACVR1A,ACVRLK2,ALK2,FOP,SKR1,TSRI
Poids moléculaire 17 kDa
UniProt Q04771
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % gly
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Stock -20 °C,-80 °C
Stockage commentaire Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Date de péremption 12 months
Images (Fournisseur)
 image for Activin Receptor Type I (ACRV1) (AA 1-124), (Extracellular Domain) protein (His tag) (ABIN3218786) Activin Receptor Type I (ACRV1) (AA 1-124), (Extracellular Domain) protein (His tag)
Background publications Renlund, ONeill, Zhang, Sidis, Teixeira: "Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor." dans: The Journal of endocrinology, Vol. 195, Issue 1, pp. 95-103, 2007 (PubMed).

Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva." dans: Nature genetics, Vol. 38, Issue 5, pp. 525-7, 2006 (PubMed).

Macías-Silva, Hoodless, Tang, Buchwald, Wrana: "Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2." dans: The Journal of biological chemistry, Vol. 273, Issue 40, pp. 25628-36, 1998 (PubMed).

ten Dijke, Yamashita, Ichijo, Franzén, Laiho, Miyazono, Heldin: "Characterization of type I receptors for transforming growth factor-beta and activin." dans: Science (New York, N.Y.), Vol. 264, Issue 5155, pp. 101-4, 1994 (PubMed).

Attisano, Cárcamo, Ventura, Weis, Massagué, Wrana: "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors." dans: Cell, Vol. 75, Issue 4, pp. 671-80, 1993 (PubMed).

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