CTLA4 Protein (AA 37-162) (Fc Tag)

N° du produit ABIN4949091

Détail du produit

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Type de proteíne: Recombinant

Attributs du protein: AA 37-162

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CTLA4 protéine est marqué à la Fc Tag.

Application: Functional Studies (Func)

Séquence: AA 37-162

Attributs du produit: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 100 kDa under non-reducing (NR) condition.

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 0.1 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Référence

Zhao, Lee, Lin, Gassen, Xu, Huang, Xiao, Bonorino, Lu, Bui, Hui: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." dans: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).

Détail du antigène

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CTLA-4 (CTLA4 Produits)

Synonymes: CTLA-4 Protein, CTLA4 Protein, CD152 Protein, Cd152 Protein, Ctla-4 Protein, Ly-56 Protein, CD Protein, CELIAC3 Protein, GRD4 Protein, GSE Protein, IDDM12 Protein, sCTLA4 Protein, cytotoxic T-lymphocyte associated protein 4 Protein, cytotoxic T-lymphocyte-associated protein 4 Protein, CTLA4 Protein, Ctla4 Protein

Sujet: CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Poids moléculaire: 40.6 kDa

ID gène: 18, 17

NCBI Accession: NP_005205

Pathways: Cancer Immune Checkpoints