nectin-3 Protein (AA 58-400) (Fc Tag)

N° du produit ABIN4949138

Détail du produit

Antigène: nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 58-400

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette nectin-3 protéine est marqué à la Fc Tag.

Application: Functional Studies (Func)

Séquence: AA 58-400

Attributs du produit: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.3 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Autre désignation: Nectin-3 (NECTIN3 Produits)

Synonymes: PVRL3 Protein, CD113 Protein, CDW113 Protein, NECTIN-3 Protein, PPR3 Protein, PRR3 Protein, PVRR3 Protein, 2610301B19Rik Protein, 3000002N23Rik Protein, 4921513D19Rik Protein, AA407785 Protein, AU016832 Protein, AW538082 Protein, nectin cell adhesion molecule 3 Protein, poliovirus receptor-related 3 Protein, Nectin3 Protein, NECTIN3 Protein, PVRL3 Protein, nectin3 Protein

Sujet: Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.

Poids moléculaire: 64.3 kDa

UniProt: Q9NQS3

Pathways: Cell-Cell Junction Organization