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CD276 Protein (CD276) (AA 29-244) (His tag)

CD276 Origine: Souris Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func
N° du produit ABIN4949154
  • Antigène Voir toutes CD276 Protéines
    CD276
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 29-244
    Origine
    • 28
    • 12
    • 3
    • 2
    Souris
    Source
    • 29
    • 5
    • 5
    • 3
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette CD276 protéine est marqué à la His tag.
    Application
    Functional Studies (Func)
    Séquence
    AA 29-244
    Attributs du produit
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.4 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Pureté
    >95 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD276 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
  • Du, Hirabayashi, Ahn, Kren, Montgomery, Wang, Tiruthani, Mirlekar, Michaud, Greene, Herrera, Xu, Sun, Chen, Ma, Ferrone, Pylayeva-Gupta, Yeh, Liu, Savoldo, Ferrone, Dotti: "Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells." dans: Cancer cell, Vol. 35, Issue 2, pp. 221-237.e8, (2019) (PubMed).

  • Antigène
    CD276
    Autre désignation
    B7-H3 (CD276 Produits)
    Synonymes
    sc:d0645 Protein, zgc:158279 Protein, 6030411F23Rik Protein, AU016588 Protein, B7RP-2 Protein, B7h3 Protein, B7H3 Protein, 4Ig-B7-H3 Protein, B7-H3 Protein, CD276 molecule Protein, CD276 molecule S homeolog Protein, CD276 antigen Protein, Cd276 molecule Protein, CD276 Protein, cd276.S Protein, cd276 Protein, Cd276 Protein
    Sujet
    B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
    Poids moléculaire
    25.4 kDa
    NCBI Accession
    NP_598744
    Pathways
    Cancer Immune Checkpoints
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