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SNCA Protein (full length)

SNCA Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant 92% pure using SDS-PAGE analysis. SDS, WB, in vitro, in vivo Active
N° du produit ABIN5065824
  • Antigène Voir toutes SNCA Protéines
    SNCA (Synuclein, alpha (SNCA))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    full length
    Origine
    • 27
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 28
    • 13
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)
    Séquence
    MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
    Specificité
    ~14.46 kDa
    Purification
    Ion-exchange Purified
    Pureté
    92% pure using SDS-PAGE analysis.
    Biological Activity Comment
    Does not induce Lewy body inclusion formation in Sprague-Dawley rat primary hippocampal neurons. Thioflavin T emission curve shows only a small increase in fluorescence (indicative of alpha synuclein aggregation) when Type 2 alpha synuclein PFFs (SPR-317) are combined with alpha synuclein monomers (SPR-321 or SPR-316). Certain biological activities in other neuronal cells cannot be ruled out. Researchers should test compatibility prior to use.
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    Discover our top product SNCA Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Certified 92% pure using SDS-PAGE analysis.

    Restrictions
    For Research Use only
  • Concentration
    Lot specific
    Buffer
    PBS pH 7.4
    Stock
    -80 °C
  • Antigène
    SNCA (Synuclein, alpha (SNCA))
    Autre désignation
    Alpha Synuclein (SNCA Produits)
    Synonymes
    snca Protein, MGC64356 Protein, LOC619283 Protein, NACP Protein, alphaSYN Protein, PARK1 Protein, PARK4 Protein, PD1 Protein, synuclein alpha L homeolog Protein, alpha-synuclein Protein, synuclein alpha Protein, synuclein, alpha Protein, snca.L Protein, LOC619283 Protein, SNCA Protein, Snca Protein
    Sujet
    Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
    Poids moléculaire
    14.46 kDa
    ID gène
    6622
    NCBI Accession
    NP_000336
    UniProt
    P37840
    Pathways
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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